There is a good article on Myalgic encephalomyelitis in The Economist, accurately (as far as I can tell) reporting the current state of research and the growing realization that this disease does in fact have a biological basis and is not the a syndrome of malingering from people wanting attention.
ME is a harrowing experience for those that suffer it and a drain on energy, social life and economy of their families. A complicated, exclusionary diagnosis and the fact that the loss of energy puts the patient in an especially weak position vis-a-vis the medical bureaucracy means that many suffer more and longer than they should. It is not being "burned out", "hitting a wall" and is not caused by stress or depression. It might cause depression in the patient, on the other hand, from being in a continually exhausted state.
A diagnostic test would help enormously. At present, a patient can go for years without adequate treatment because many doctors do not recognize ME/CFS as an illness at all. If the illness can be diagnosed fast, the patient can be helped faster – and will face less of a challenge understanding and making the surroundings understand what the problem is.